エバラ　サトミ   EBARA SATOMI   榎原　智美    所属   看護学部 看護学科    職種   教授
発表年月日	2025/07/27
発表テーマ	Three-dimensional ultrastructure to macroscopic afferent analysis of mechanoreceptor neurons
会議名	第48回日本神経科学学会
主催者	日本神経科学会
学会区分	全国学会
発表形式	ポスター
単独共同区分	共同
開催地名	新潟市
開催期間	2025/07/26～2025/07/28
発表者・共同発表者	榎原智美, 小池太郎, 外村宗達, 村本大河, 古田貴寛
概要	Mechanoreceptors are densely distributed in mammalian whisker follicles, each exhibiting distinct structures and responses during whisking. To characterize Ruffini-like endings, we performed multiscale morphological analyses using FIB-SEM, micro-X-ray CT, and serial reconstructions. These endings are located at the cavernous sinus level beneath the glassy membrane and form extensively branched two-dimensional networks. Axon terminals, ensheathed by terminal Schwann cells, are embedded in dense collagen fibers, surrounded by a fibroblast-rich framework with associated elastic fibers. Reconstruction revealed a complex microenvironment resembling a “collagenous ocean.” In addition, fiber tracing showed compact bundling of trigeminal afferents at the nerve root. These findings provide insight into how peripheral nanoscale information is organized for transmission to the brain.