サワダ　タダシ   澤田　規    所属   保健医療学部 柔道整復学科    職種   教授
言語種別	英語
発行・発表の年月	2004/06
形態種別	研究論文（学術雑誌）
査読	査読あり
標題	Xenon suppresses nociceptive reflex in newborn rat spinal cord in vitro; comparison nitrous oxide
執筆形態	共著
掲載誌名	European Journal of Pharmacology 496(2004)
掲載区分	国内
巻・号・頁	pp.71-76
担当範囲	実験およびデータ解析を担当した．
著者・共著者	Ippei Watanabe, Makoto Takenosita, Tadashi Sawada, Ichirou Uchida, Takashi, Mashimo
概要	Although analgesic action of xenon has been reported, little is known about the effect of xenon at the spinal cord, which plays acrucial role in nociceptive transmission. We studied the effect of xenon on nociceptive (the slow ventral root potential) and the monosynaptic reflex in neonatal rat spinal cord in vito in comparison with nitrous oxide. Xenon(30%) and nitrous oxide(30%) were applied for 17 min through superfusing artificial cerebrospinal fluid. Xenon and nitrous oxide significantly reduced the amplitude of nociceptive reflex by ～70% and ～25%, respectively. Xenon and nitrous oxide also significantly reduced the amplitude of the monosynaptic reflex by ～35% and ～15%, respectively. These results indicate that xenon suppressed the synaptic transmission at the spinal cord, especially those of the slow ventral root potential, which reflect nociceptive transmission．