教員教育・研究情報 - 高橋　達雄

タカハシ　タツオ Tatsuo Takahashi
高橋　達雄

所属北陸大学薬学部薬学科

職種教授

著書・論文歴
その他	第26回日本骨粗鬆症学会を終えていしかわ県薬レポート 92,40-43頁 (単著) 2025/01
論文	Effects of Aging on Intramuscular Collagen-Related Factors After Injury to Mouse Tibialis Anterior Muscle. Int J Mol Sci 26 (2) (共著) 2025/01
著書	Investigation of the Antimicrobial Activity and Cell Viability of Myticalin A6 (3-23)-(Trp-Pro-Arg)n-OH Derivatives.,113-114頁 (共著) 2024
論文	Spectral and HPLC Analyses of Synthesized Butin and Butein. Chem Pharm Bull (Tokyo) 72 (7),648-657頁 (共著) 2024
論文	The Effects of Aging on Sarcoplasmic Reticulum-Related Factors in the Skeletal Muscle of Mice. Int J Mol Sci 25 (4) (共著) 2024
論文	Effects of Obesity in Old Age on the Basement Membrane of Skeletal Muscle in Mice. Int J Mol Sci 24 (11) (共著) 2023
著書	Study of the Antimicrobial Activity and Cell Viability of N-Fatty Acylated or Tryptophan Substituted Myticalin A6 (3-23)-OH Derivatives Peptide Science 2022,115-116頁 (共著) 2023
論文	Effects of stretching on the basement membrane structure in the soleus muscle of Wistar rats. Med Mol Morphol 56 (1),11-19頁 (共著) 2023
著書	Investigation of the Antimicrobial Activity, Cell Viability, and Hemolytic Activity of N-Fatty Acylated Myticalin A6 (3-23)-OH Derivatives. Peptide Science 2021,157-158頁 (共著) 2022
その他	骨・関節疾患　疾患各論臨床薬学テキストシリーズ　呼吸器/免疫・炎症・アレルギー/骨・関節,256-288頁 (共著) 2020
論文	The active ingredients in the anti-obesity drug bofutsushosan in high-fat-diet-fed obese mice. Traditional & Kampo Medicine (共著) 2020
論文	Tetrandrine increases the sensitivity of human lung adenocarcinoma PC14 cells to gefitinib by lysosomal inhibition. Anticancer Res 39 (12) (共著) 2019
論文	Effect of genetic polymorphism of brain-derived neurotrophic factor and serotonin transporter on smoking phenotypes: A pilot study of Japanese participants. Heliyon 5 (2) (共著) 2019
その他	薬剤師でなくても知っておきたい薬の話　第4回よく効く遺伝子、効かない遺伝子 Osteoporosis Japan Plus 3 (4),56-57頁 (共著) 2018
その他	薬剤師でなくても知っておきたい薬の話　第3回投与計画はどうやって立てる？ Osteoporosis Japan Plus 3 (3),48-49頁 (共著) 2018
その他	薬剤師でなくても知っておきたい薬の話　第2回副作用、相互作用はなぜ起こる Osteoporosis Japan Plus 3 (2),48-50頁 (共著) 2018
その他	薬剤師でなくても知っておきたい薬の話　第1回薬物動態はむずかしくない！ Osteoporosis Japan Plus 3 (1),44-47頁 (共著) 2018
論文	Mechanism of Gardeniae Fructus for the anti-diabetic action in high-fat diet-fed and streptozotocin-treated diabetic mice. Asian Journal of Traditional Medicines 12 (1),19-30頁 (共著) 2017
論文	Mechanisms for the anti-obesity actions of bofutsushosan in high-fat diet-fed obese mice. Chin Med (共著) 2017
論文	Effect of impaired tissue function on pharmacokinetics of anti-osteoporotic drugs. Clin Calcium 26 (11),1539-1545頁 (単著) 2016
論文	Improved therapeutic efficacy in bone and joint disorders by targeted drug delivery to bone. Yakugaku Zasshi 136 (11),1501-1508頁 (単著) 2016
論文	Enzyme replacement therapy in newborn mucopolysaccharidosis IVA mice: Early treatment rescues bone lesions? Mol Genet Metab 114 (2),195-202頁 (共著) 2015
論文	骨指向性薬物の創製と骨・関節疾患治療への応用 Applied Cell Biology 28,1-9頁 (単著) 2015
論文	Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population. BMC Genet (共著) 2014
論文	Anti-Hyperglycemic Effect of Single Administered Gardeniae Fructus in Streptozotocin-Induced Diabetic Mice by Improving Insulin Resistance and Enhancing Glucose Uptake in Skeletal Muscle. Chinese Medicine 4,157-165頁 (共著) 2013
論文	Bone-targeting endogenous secretory receptor for advanced glycation end products rescues rheumatoid arthritis. Mol Med 19,183-194 (共著) 2013
論文	Effect of single administered Bofutsushosan-composed crude drugs on diabetic serum parameters in streptozotocin-induced diabetic mice. Chinese Medicine 4,24-31 (共著) 2013
論文	Tetrandrine prevents bone loss in sciatic-neurectomized mice and inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclast differentiation. Biol Pharm Bull 35,1765-1774 (共著) 2012
その他	粉防已成分tetrandrineの骨粗鬆症治療効果応用細胞補完代替医療学 1,76-80 (共著) 2012/12
論文	Effects of Bofutsushosan and Gardenia Fruit on diabetic serum parameters in Streptozotocin-induced diabetic mice. Chinese Medicine 2,130-137 (共著) 2011
論文	Inhibitory actions of tetrandrine on tumor necrosis factor alpha-induced NF-kappaB activation in neovascularization of cultured choroidal explants. Chinese Medicine 1,75-83 (共著) 2010
論文	23-Hydroxyursolic acid causes cell growth-inhibition by inducing caspase-dependent apoptosis in human cervical squamous carcinoma HeLa cells. Anticancer Res 29,995-1000 (共著) 2009
論文	Selective drug delivery to bone using acidic oligopeptides. J Bone Miner Metab 27,1-8 (共著) 2009
論文	Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice. Mol Genet Metab 94,178-189 (共著) 2008
論文	Bone-targeting of quinolones conjugated with an acidic oligopeptide. Pharm Res 25,2881-2888 (共著) 2008
論文	Enzyme replacement therapy in a murine model of Morquio A syndrome. Hum Mol Genet 17,815-824 (共著) 2008
論文	Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells. Biol Pharm Bull 31,1403-1409 (共著) 2008
論文	Inotosiol, a lanostane triterpenoid, from Inototus obliquus inhibits cell proliferation through caspase-3 dependent apoptosis. Anticancer Res 28,2691-2696 (共著) 2008
論文	Targeted drug delivery to bone; pharmacokinetic and pharmacological properties of acidic oligopeptide-tagged drugs. Curr Drug Discov Technol 5,39-48 (共著) 2008
論文	Characterization and pharmacokinetic study of recombinant human N-acetylgalactosamine-6-sulfate sulfatase. Mol Genet Metab 91,69-78 (共著) 2007
論文	Combined effects of fangchinoline from Stephania tetrandra Radix and formononetin and calycosin from Astragalus membranaceus Radix on hyperglycemia and hypoinsulinemia in streptozotocin-diabetic mice. Biol Pharm Bull 30,2079-2083 (共著) 2007
論文	Inhibition of tetrandrine on epidermal growth factor-induced cell transformation and its signal-transduction. Anticancer Res 27,3187-3194 (共著) 2007
著書	Mucopolysaccharidosis IV (Morquio Syndrome) Lysosomal Storage Disorders,433-445頁 (共著) 2007
論文	Overproduction of Nepsilon-(carboxymetyl) lysine-induced neovascularization in cultured chroidal explant of aged rat. Biol Pharm Bull 30,133-138 (共著) 2007
論文	Structure-activity relationship of flavonoids for inhibition of epidermal growth factor-induced transformation of JB6 Cl 41 cells. Mol Carcinog 46,436-445 (共著) 2007
論文	Determinant factors of spectrum of missense variants in mucopolysaccharidosis IVA gene. Mol Genet Metab 89,139-149 (共著) 2006
論文	Differences in methylation patterns in the methylation boundary region of IDS gene in Hunter syndrome patients: implications for CpG hot spot mutations. Eur J Hum Genet 14,838-845 (共著) 2006
論文	Enhancement of drug delivery to bone: characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic oligopeptide. Mol Genet Metab 88,244-255 (共著) 2006
論文	Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors. Proc Natl Acad Sci U S A 103,15172-15177 (共著) 2006
論文	Pharmacokinetic advantage of an intranasal preparation of a novel anti-osteoporosis drug, L-asp-hexapeptide-conjugated estradiol. Biol Pharm Bull 29,1229-1233 (共著) 2006
論文	Phosphodiesterase 4 inhibitor rolipram potentiates the inhibitory effect of calcitonin on osteoclastogenesis. J Bone Miner Metab 24,260-265 (共著) 2006
論文	Development of MPS IVA mouse (Galnstm(hC79S.mC76S)slu) tolerant to human N-acetylgalactosamine-6-sulfate sulfatase. Hum Mol Genet 14,3321-3335 (共著) 2005
論文	Heparan sulfate levels in mucopolysaccharidoses and mucolipidoses. J Inherit Metab Dis 28,743-757 (共著) 2005
論文	Keratan sulphate levels in mucopolysaccharidoses and mucolipidoses. J Inherit Metab Dis 28,187-202 (共著) 2005
論文	Mutation and polymorphism spectrum of the GALNS gene in mucopolysaccharidosis IVA (Morquio A). Hum Mutat 26,500-512 (共著) 2005
論文	Development and testing of new screening method for keratan sulfate in mucopolysaccharidosis IVA. Pediatr Res 55,592-597 (共著) 2004
論文	General implications for CpG hot spot mutations: methylation patterns of the human iduronate-2-sulfatase gene locus. Hum Mutat 23,590-598 (共著) 2004
論文	Identification of a common mutation in mucopolysaccharidosis IVA: correlation among genotype, phenotype, and keratan sulfate. J Hum Genet 49,490-494 (共著) 2004
論文	Inhibition of osteoclastogenesis by a phosphodiesterase 4 inhibitor XT-611 through synergistic action with endogenous prostaglandin E2. Biochem Pharmacol 66,801-807 (共著) 2004
論文	Inhibitory mechanism of caffeine on insulin-stimulated glucose uptake in adipose cells. Biochem Pharmacol 68,1929-1937 (共著) 2004
論文	Mouse model of N-acetylgalactosamine-6-sulfate sulfatase deficiency (Galns-/-) produced by targeted disruption of the gene defective in Morquio A disease. Hum Mol Genet 12,3349-3358 (共著) 2004
論文	Mucopolysaccharidosis IVA (Morquio A): identification of novel common mutations in the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) gene in Italian patients. Hum Mutat 24,187-188 (共著) 2004
論文	Mucopolysaccharidosis IVA: identification of mutations and methylation study in GALNS gene. J Med Genet 41,e98 (共著) 2004