教員教育・研究情報 - 東　康彦

ヒガシ　ヤスヒコ
東　康彦

所属北陸大学薬学部薬学科

職種教授

著書・論文歴
論文	Improved method for determination of raspberry ketone in fragrance mist by HPLC-fluorescence analysis after pre-column derivatization with 4-(N,N-dimethylaminosulfonyl)-7-(N-chloroformylmethyl-N-methylamino)-2,1,3-benzoxadiazole J. Anal. Sci. Methods and Instrumentation 8 (2),17-24頁 (単著) 2018
論文	HPLC analysis of hinokitiol in skin lotion with visible light detection after pre-column dabsylation Am. J. Anal. Chem. 8 (5),345-354頁 (共著) 2017
論文	Simple HPLC–UV analysis of phenol and its related compounds in tap water after pre-column derivatization with 4-nitrobenzoyl chloride. J. Anal. Sci. Methods and Instrumentation 7 (1),18-28頁 (単著) 2017
論文	Combination of pretreatments with acetic acid and sodium methoxide for efficient digoxin preparation from digitalis glycosides in Digitalis lanata leaves Pharmacol. Pharm. 7 (5),200-207頁 (共著) 2016
論文	Development of highly specific enzyme immunoassay for monitoring serum digitoxin level in patients J. Anal. Sci. Methods and Instrumentation 6 (2),15-22頁 (共著) 2016
論文	Development of simultaneous HPLC-fluorescence assay of phenol and chlorophenols in tap water after pre-column derivatization with 3-chlorocarbonyl-6,7-dimethoxy-1-methyl-2(1H)-quinoxalinone Detection 4 (1),16-24頁 (単著) 2016
論文	Simple HPLC-fluorescence determination of raspberry ketone in fragrance mist after pre-column derivatization with 4-hydrazino-7-nitro-2,1,3-benzoxadiazole J. Anal. Sci. Methods and Instrumentation (単著) 2016
論文	Determination of three phenylphenols in grapefruit juice by high-performance liquid chromatography after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole J. Anal. Chem. 70 (3) (共著) 2015
論文	Establishment of a highly specific enzyme immunoassay for digoxin in human serum Jacobs J. Nanomed. Nanotech.. 1 (1),1-6頁 (共著) 2015
論文	Simple determination of 17α-ethynylestradiol in hair restorer by high-performance liquid chromatography coupled with fluorescence detection after pre-column derivatization with 4-(N-chloroformylmethyl-N-methylamino)-7-nitro-2,1,3-benzoxadiazole Austin Chromatography 2 (2),1-4頁 (単著) 2015
論文	Simple determination of o-phenylphenol in skin lotion by high-performance liquid chromatography coupled with fluorescence detection after pre-column derivatization with 4-(N-chloroformylmethyl-N-methylamino)-7-nitro-2,1,3-benzoxadiazole J. Cosmet. Sci. 66 (2),129-137頁 (共著) 2015
論文	Simple HPLC-fluorescence determination of eugenol in clove oil after pre-column derivatization with 4-(N-chloroformylmethyl-N-methylamino)-7-nitro-2,1,3-benzoxadiazole. J. Anal. Chem. 70 (11),1401-1405頁 (単著) 2015
論文	Simultaneous analysis of honokiol and magnolol in rat serum by HPLC with fluorescence detection after solid-phase extraction for pharmacokinetic studies Austin J. Anal. Pharm. Chem. 2 (2),1-5頁 (単著) 2015
論文	Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in db/db mice. Food Funct. 5 (2),214-219頁 (共著) 2014
論文	Determination of hinokitiol in skin lotion by high-performance liquid chromatography-ultraviolet detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole. J. Cosmet. Sci. (共著) 2013
論文	High-performance liquid chromatography coupled with fluorescence detection for simultaneous determination of honokiol and magnolol in Hange-Koboku-To dried extract granules. 35 (2),321-330 (共著) 2012
論文	HPLC-UV analysis of kojic acid in a skin-whitening cosmetic after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole. J. Cosmet. Sci. 63 (2),205-212 (共著) 2012
論文	Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress. J. Trad. Med. 29 (3),124-136 (共著) 2012
論文	HPLC-UV analysis of eugenol in clove and cinnamon oils after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole J. Liq. Chromatogr. & Rel. Technol. 34 (1),18-25 (共著) 2011
論文	Determination of fluoxetine enantiomers in human serum and urine by isocratic HPLC and pre-column fluorescence derivatization with (R)-(+)-4-nitro-7-(2-chloroformylpyrrolidin-1-yl)-2,1,3-benzoxadiazole J. Liq. Chromatogr. & Rel. Technol. 33 (4),481-490 (共著) 2010
論文	In vitro inhibition of alpha-glucosidases and glycogen phosphorylase by catechin gallates in green tea Food Chem. 122,1061-1066 (共著) 2010
論文	Simple determination of fluoxetine and norfluoxetine in human serum and urine by dabsylation followed by HPLC with visible light detection J. Liq. Chromatogr. & Rel. Technol. 33 (14),1405-1415 (共著) 2010
論文	Determination of fluoxetine and norfluoxetine in human serum and urine by HPLC using a cholester column with fluorescence detection J. Liq. Chromatogr. & Rel. Technol. 32 (7),1141-1151 (共著) 2009
論文	High-performance liquid chromatography with dual-wavelength ultraviolet detection for measurement of hinokitiol in personal care products J. Cosmet. Sci. 60 (5),519-525 (共著) 2009
論文	HPLC-UV analysis of phenol and chlorophenols in water after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole J. Liq. Chromatogr. & Rel. Technol. 32 (16),2327-2383 (共著) 2009
論文	Simultaneous determination of N-dealkylated metabolites of four butyrophenone-type agents by HPLC with fluorescence detection after pre-column derivatization with dansyl chloride J. Liq. Chromatogr. & Rel. Technol. 31 (18),2762-2770 (共著) 2008
論文	Simultaneous determination of four basic metabolites of butyrophenone-type agents in rat plasma by high-performance liquid chromatography with fluorescence detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole J. Liq. Chromatogr. & Rel. Technol. 30 (18),2747-2754 (共著) 2007
論文	シクロスポリンAとメシル酸イマチニブの薬物間相互作用の検討を行った骨髄移植患者の2症例 TDM研究 24 (2),137-143 (共著) 2007
論文	Effect of imatinib mesilate on the disposition kinetics of ciclosporin in rats J. Pharm. Pharmacol. 58 (7),997-1000 (共著) 2006
論文	Sensitive determination of 4-(4-bromophenyl)-4-hydroxypiperidine, a metabolite of bromperidol, in rat plasma by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole Biol. Pharm. Bull. 29 (12),2479-2482 (共著) 2006
論文	Sensitive determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, in a rat biological sample by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole Biomed. Chromatogr. 20 (9),964-970 (共著) 2006
論文	Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone-type neuroleptics by high performance liquid chromatography with dual ultraviolet detection Biomed. Chromatogr. 20 (2),166-172 (共著) 2006
論文	Simultaneous determination of four basic metabolites formed from butyrophenone-type agents in phosphate-buffered saline by high-performance liquid chromatography with dual ultraviolet detection J. Liq. Chromatogr. & Rel. Technol. 29 (19),2853-2862 (共著) 2006
論文	Simultaneous liquid chromatographic assay of amantadine and its four related compounds in phosphate-buffered saline using 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorescent derivatization reagent Biomed. Chromatogr. 20 (5),423-428 (共著) 2006
論文	Determination of fluvoxamine in rat plasma by HPLC with pre-column derivatization and fluorescence detection using 4-fluoro-7-nitro-2,1,3-benzoxadiazole Biomed. Chromatogr. 19 (10),771-776 (共著) 2005
論文	Pharmacokinetic interaction with digoxin and glucocorticoids in rats detected by radio-immunoassay using a novel specific antiserum Life Sci. 77 (9),1055-1067 (共著) 2005
論文	Simultaneous determination of amantadine and rimantadine by HPLC in rat plasma with pre-column derivatization and fluorescence detection for pharmacokinetic studies Biomed. Chromatogr. 19 (9),655-662 (共著) 2005
論文	Simultaneous determination of the binding of amantadine and its analogues to synthetic melanin by liquid chromatography after precolumn derivatization with dansyl chloride J. Chromatogr. Sci. 43 (4),213-217 (共著) 2005
論文	Liquid chromatographic determination of 1-adamantanamine and 2-adamantanamine in human plasma after pre-column derivatization with o-phthalaldehyde and 1-thio-beta-D-glucose J. Chromatogr. B 799 (2),349-354 (共著) 2004
論文	Sensitive determination of the binding of antidepressants to synthetic melanin by liquid chromatography after pre-column derivatization with dansyl chloride J. Liq. Chromatogr. & Rel. Technol. 27 (12),1903-1914 (共著) 2004
論文	HPLC analysis of bucillamine by derivatization with N-(1-pyrenyl)maleimide in human blood J. Liq. Chromatogr. & Rel. Technol. 26 (19),3261-3271 (共著) 2003
論文	Measurement of beta-methyldigoxin level in serum from patients by enzyme immunoassay using novel specific antiserum with a phenyl boric acid column Ther. Drug Monit. 25 (4),452-456 (共著) 2003
論文	Pharmacokinetic study of beta-methyldigoxin by enzyme immunoassay using a novel specific antiserum in rats Biol. Pharm. Bull. 26 (2),247-251 (共著) 2003
論文	Establishment of enzyme immunoassay for measuring beta-methyldigoxin levels in human serum by specific antiserum Biol. Pharm. Bull. 25 (10),1251-1257 (共著) 2002
論文	Modulation of mdr1a and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone Biochem. Pharmacol. 63 (4),777-783 (共著) 2002
論文	Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice J. Pharm. Pharmacol. 54 (4),527-533 (共著) 2001
論文	Novel drug delivery system to bone using acidic oligopeptide: Pharmacokinetic characteristics and pharmacological potential J. Drug Target. 9 (2),111-121 (共著) 2001
論文	Selective delivery of estradiol to bone by aspartic acid oligopeptide and its effects on ovariectomized mice Endocrinology 142 (3),1228-1233 (共著) 2001
論文	Characteristics of L-carnitine transport in cultured human hepatoma HLF cells J. Pharm. Pharmacol. 51 (8),935-940 (共著) 1999
論文	Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice J. Pharmacol. Exp. Ther. 289 (1),224-230 (共著) 1999
論文	Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice Hepatology, 30(4): 997－1001 (1999). 30 (4),997-1001 (共著) 1999
その他	先天的カルニチン欠損JVSマウスの脂肪肝に与えるガンマ-ブチロベタインの効果日本臨床薬理学会 31 (3),443-444 (共著) 2000