教員教育・研究情報 - 大畠　京子

オバタケ　キヨウコ
大畠　京子

所属北陸大学薬学部薬学科

職種教授

著書・論文歴
論文	Regulation of Matrix Metalloproteinases-2 and -9 Gene Expression in Cultured Human Fetal Membrane Cells by Influenza Virus Infection. Biol Pharm Bull. 39 (12),1912-1921頁 (共著) 2016/12
論文	Iminosugar-Based Galactoside Mimics as Inhibitors of Galactocerebrosidase: SAR Studies and Comparison with Other Lysosomal Galactosidases. ChemMedChem. 9 (12),2647-2652頁 (共著) 2014/12
論文	Effects of eugenol-reduced clove extract on glycogen phosphorylase b and the development of diabetes in the db/db mice. Food Funct. 5 (2),214-219頁 (共著) 2014/02
論文	Glucosylceramide Mimics: Highly potent GCase inhibitors and selective pharmacological chaperones for mutations associated with types 1 and 2 Gaucher disease. ChemMedChem. 8 (11),1805-1817頁 (共著) 2013/11
論文	Protecting effect of the Sasa extract against endothelial dysfunction by hyperglycemia-induced oxidative stress. J. Trad. Med. 29,124-136 (共著) 2012/07
論文	Cyclodextrin-based iminosugar click clusters: the first examples of multivalent pharmacological chaperones for the treatment of lysosomal storage disorders. ChemMedChem. 13,661-664 (共著) 2012/03
論文	Second-generation iminoxylitol-based pharmacological chaperones for the treatment of Gaucher disease. ChemMedChem. 6,353-361 (共著) 2011/02
論文	In vitro inhibition of alpha-glucosidases and glycogen phosphorylase by catechin gallates in green tea. Food Chemistry 122,1061-1066 (共著) 2010/10
論文	2,5-Dideoxy-2,5-imino-D-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg. Med. Chem. 18,3790-3794 (共著) 2010/06
論文	Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors. Bioorg. Med. Chem. 18,2645-2650 (共著) 2010/04
論文	Design, synthesis and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease ChemMedChem. 4,378-392 (共著) 2009/03
論文	Stereodivergent access to polyhydroxylated 10-azabicyclo[4.3.1]decanes as new calystegine analogues. J. Org. Chem. 74,3179-3182 (共著) 2009/03
論文	In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg. Med. Chem. 16,7330-7336 (共著) 2008/08
論文	Efficient syntheses of optically pure chiro- and allo-inositol derivatives, azidocyclitols and aminocyclitols from myo-inositol. Tetrahedron 64,4072-4080 (共著) 2008/04
論文	Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases. Bioorg. Med. Chem. 16,2732-2740 (共著) 2008/03
論文	Iminosugars from Baphia nitida Lodd. Phytochemistry 69,1261-1265 (共著) 2008/03
論文	Synthesis of 4-O-glycosylated 1-deoxynojirimycin derivatives as disaccharide mimics-based inhibitors of human beta-glucocerebrosidase. Carbohydr Res. 342,1960-1965 (共著) 2007/09
論文	Assessment of the perinatal effects of maternal ingestion of Ipomoea carnea in rats. Exp Toxicol Pathol. 58,439-446 (共著) 2007/08
論文	Efficient synthesis from D-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-L-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases. Tetrahedron Lett. 48,4287-4291 (共著) 2007/06
論文	Isolation of Glycosidase-Inhibiting Hyacinthacines and Related Alkaloids from Scilla socialis. J. Nat. Prod. 70,993-997 (共著) 2007/06
論文	alpha-1-C-Octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease. Bioorg. Med. Chem. 14,7736-7744 (共著) 2006/12
論文	Design and synthesis of highly potent and selective pharmacological chaperones for the treatment of Gaucher's disease. Chembiochem. 7,1356-1359 (共著) 2006/06
論文	Inhibitory effect of dipeptide alcohol derivatives containing mercapto group on eukaryotic DNA polymerase alpha. Int. J. Mol. Med.Int. 16,653-659 (共著) 2005/10
論文	Iminosugar-Producing Thai Medicinal Plants. J. Nat. Prod. 68,1238-1242 (共著) 2005/08
論文	Biological properties of D- and L-1-deoxyazasugars. J. Med. Chem. 48,2036-2044 (共著) 2005/03
論文	Dipeptide alcohol-based inhibitors of eukaryotic DNA polymerase alpha. Bioorg. Med. Chem. 13,2187-2196 (共著) 2005/03
論文	General synthesis and biological evaluation of alpha-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-alpha-C-glycosides). Bioorg. Med. Chem. 13,2313-2324 (共著) 2005/03
論文	Synthesis of a trihydroxylated azepane from D-arabinose by way of an intramolecular alkene nitrone cycloaddition. Tetrahedron: Asymmetry 16,223-229 (共著) 2005/01
論文	The L-enantiomers of D-sugar-mimicking iminosugars are noncompetitive inhibitors of D-glycohydrolase? Tetrahedron: Asymmetry 16,223-229 (共著) 2005/01
論文	alpha-1-C-Alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitor of intestinal isomaltase: remarkable effect of the alkyl chain-length on glycosidase inhibitory profile. Bioorg. Med. Chem. Lett. 14,5991-5995 (共著) 2004/12
論文	Efficient routes to optically active azide-, amino-, diazido- and diaminocyclitols with chiro and allo configuration from myo-inositol. Tetrahedron Lett. 45,pp. 8367-8370 (共著) 2004/11
論文	Looking-glass inhibitors: L-DMDP, a more potent and specific inhibitor of alpha-glucosidases than the enantiomeric natural product DMDP. Chem. Comm. 67,1936-1937 (共著) 2004/07
論文	Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side-chain in Scilla peruviana. J. Nat. Prod. 67,846-850 (共著) 2004/05
論文	Synthesis and biological evaluation of the first example of an eight-membered iminoalditol. Tetrahedron Lett. 45,579-581 (共著) 2004/01
論文	Alkaloids from the poisonous plant Ipomoea carnea: effects on intracellular lysosomal glycosidase activities in human lymphoblast cultures. J. Agric. Food Chem. 51,7642-7646 (共著) 2003/12
論文	Alkaloidal components in the poisonous plant, Ipomoea carnea (Convolvulaceae). J. Agric. Food Chem. 51,4995-5000 (共著) 2003/08
論文	Chemoenzymatic syntheses of (-)-1-deoxymannojirimycin (DMJ) and its naturally occurring 6-O-alpha-L-rhamnopyranosyl glycoside. Org. Biomol. Chem. 1,2035-2037 (共著) 2003/05
論文	Australine and related alkaloids: easy structural confirmation by ¹³C NMR spectral data and biological activities. Tetrahedron: Asymmetry 14,325-331 (共著) 2003/02
論文	First stereocontrolled synthesis and biological evaluation of 1,6-dideoxy-L-nojirimycin. Tetrahedron: Asymmetry 14,47-51 (共著) 2003/01
論文	Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J. Agric. Food Chem. 49,4208-4213 (共著) 2001/08
論文	Dihydroxynortropane alkaloids from calystegine-producing plants. Phytochemistry 57,721-726 (共著) 2001/07
論文	In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives. Eur. J. Biochem. 267,4179-4186 (共著) 2000/07
論文	Polyhydroxylated pyrrolidine and piperidine alakloids from Adenophora triphylla var. japonica (Campanulaceae). Phytochemistry 53,379-382 (共著) 2000/02
論文	Homonojirimycin analogues and their glucosides from Lobelia sessilifolia and Adenophora spp. (Campanulaceae). Carbohydr. Res. 323,73-80 (共著) 2000/01
論文	New polyhydroxylated pyrrolizidine alkaloids from Muscari armeniacum: structural determination and biological activity. Tetrahedron Asymm. 11,1-8 (共著) 2000/01
論文	Polyhydroxylated pyrrolidine and pyrrolizidine alkaloids from Hyacinthoides non-scripta and Scilla campanulata. Carbohydr. Res. 316,95-103 (共著) 1999/03
論文	Preparation and biological activity of manno- and galacto-validamines, new 5a-carba-glycosylamines as alpha-glycosidase inhibitors. Carbohydr. Res. 300,259-264 (共著) 1997/05
論文	Inhibition of the G1/S transition in A65 cells by H-7, a protein kinase C inhibitor. Biochem. Pharmacol. 45,772-775 (共著) 1993/02
論文	Effect of staurosporine derivatives on protein kinase activity and vinblastine accumulation in mouse leukaemia P388/ADR cells. J. Pharm. Pharmacol. 45,43-47 (共著) 1993/01