教員教育・研究情報 - 木村　敏行

キムラ　トシユキ TOSHIYUKI KIMURA
木村　敏行

所属北陸大学薬学部薬学科

職種教授

著書・論文歴
著書	衛生化学・環境健康学講義ブック　生化学〜食品衛生学〜環境学　第3版 (単著) 2014
著書	健康と環境の衛生薬学 (共著) 2010
著書	薬毒物分析学辞典 (共著) 2009
著書	Action mechanism for hypnotic activity of N3-benzyluridine and related compounds Endogenous Sleep Factor, 133-142,133-142頁 (共著) 1990
論文	2006 年から 2021 年における壊血病発症状況(その 1):　日本では自閉スペクトラム症児を中心に壊血病が増加しているビタミン 97 (3),131-137頁 (共著) 2023/03
論文	2006 年から 2021 年における壊血病発症状況(その 2): 世界では年齢に問わず壊血病が増加しているビタミン 97 (3),138-143頁 (共著) 2023/03
論文	∆9-Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB1 receptor Forensic Toxicology 37 (1),207-214頁 (共著) 2019
論文	Determination of carnosine, a histidine-containing dipeptide, in milk including human by HPLC., Peptide Sci. 2009,247-248頁 (共著) 2010
論文	鎮痛効果を持つピリミジンヌクレオシド誘導体生体の科学 60 (5),454-455 (共著) 2009/05
論文	大麻文化科学考（その19）　カンナビノイド生合成経路-再考北陸大学紀要 32,1-11頁 (共著) 2008/12
論文	大麻文化科学考（その18）　ヒトにおける大麻主成分カンナビノイドの代謝北陸大学紀要 31,1-11頁 (共著) 2008/03
論文	Nafamostat is hydrolyzed by human liver cytosolic long-chain acyl-CoA hydrolase. Xenobiotica 37,260-270頁 (共著) 2008
論文	Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling. Toxicology 245,141-146頁 (共著) 2008
論文	Butyrylcholinesterase and erythrocyte sulfhydryl-dependent enzyme hydrolyze gabexate in human blood. J. Health Sci. 53 (1),60-66頁 (共著) 2007
論文	Conversion of cannabidiol to ?9-tetrahydrocannabinol and related cannabinoids in artificial gastric juice, and their pharmacological effects in mice, Foren. Toxicol. 25,16-21頁 (共著) 2007
論文	Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes, Life Sci. 80,1415-1419頁 (共著) 2007
論文	Involvement of human blood arylesterases and liver microsomal carboxyesterases in Nafamostat hydrolysis Drug Metab. Pharmacokinet. 21 (2),147-155頁 (共著) 2006
論文	Hepatic metabolism of methyl Anthraniate and mathyl N-methylanthranilate as food flavoring agents in relation to allergenicity in the guinea pig Journal of Health Sciences 51 (6),667-675頁 (共著) 2005
論文	In vitro inhibitory effects of cannabinoids on progesterone 17α-hydroxylase activity in rat testis microsomes J. Health Sci. 51,369-375頁 (共著) 2005
論文	Marijuana extracts possess the effects like the endocrine disrupting chemicals Toxicology 206 (3),471-478頁 (共著) 2005
論文	Stereospecific and regioselective hydrolysis of cannabinoid ester by ES46.5K, an esterase from mouse hepatic microsomes, and its differences from carboxylesterase of rabbit and porcine liver Biol. Pharm. Bull. (共著) 2005
論文	Synthesis of N3-substituted uridine and related pyrimidine nucleosides and their antinociceptive effects in mice Chemical Pharmaceutical Bulletin 53 (3),313-318頁 (共著) 2005
論文	大麻文化科学考（その17）　乱用薬物防止教育北陸大学紀要 30,13-22頁 (共著) 2005
論文	大麻文化科学考（その15）　大麻からの創薬　-治療薬への応用北陸大学紀要 28,17-32頁 (共著) 2004
論文	Major cytochrome P450 enzymes responsible for microsomal aldehyde oxugenation of 11-oxo-Δ8-tetrahydrocannabinol and 9- anthraldehyde in human live Drug Metabol. Pharmacokin. 17,516-521頁 (共著) 2003
論文	N3-Phenacyluridine as a new type of antinociceptive compound in mice Res. Commun. Mol. Pathol. Pharmacol. 113,57-65頁 (共著) 2003
論文	Pharmacology and toxicology of major constituents of Marijuana - On the metabolic activation of cannabinoids and its mechanism J. Toxicol. Toxin Rev (共著) 2003
論文	大麻文化科学考（その13）北陸大学紀要 26,7-15頁 (共著) 2003
論文	大麻文化科学考（その14）　THCの活性代謝物北陸大学紀要 27,1-11頁 (共著) 2003
論文	Hypnotic Action of N3-Substituted Arabinofuranosyluracils on Mice Chem. Pharm. Bull. 49,111-113頁 (共著) 2001
論文	Possible existence of a novel receptor for uridine analogues in the central nervous system using two isomers, N3-(S)-(+)- and N3-(R)-(-)-α-hydroxy-β-phenethyluridines Biol. Pharm. Bull. 24,729-731頁 (共著) 2001
論文	Skin reaction induced by aldehydes for food flavoring agents J. Health. Sci. 47,327-329頁 (共著) 2001
論文	Synthesis and hypnotic activities of 4-thio analogues of N3-substituted uridines Chem. Pharm. Bull. 49,1185-1188頁 (共著) 2001
論文	大麻文化科学考（その12）北陸大学紀要 25,15-26頁 (共著) 2001
論文	A carbonyl reductase-catalyzing reduction of N3-phenacyluridine in rabbit liver Biol. Pharm. Bull. 23,917-921頁 (共著) 2000
論文	Cross-reactivity of various tetrahydrocannabinol metabolites with a monoclonal antibody against tetrahydrocannabinolic acid J. Health Sci. 46,310-313頁 (共著) 2000
論文	Metabolism of a novel hypnotic, N3-phenacyluridine, and hypnotic and sedative activities of its enantiomer metabolites in mouse Xenobiotica 30,643-653頁 (共著) 2000
論文	Pharmacological effects in mice of anandamide and its related fatty acid ethanolamides, and enhancement of cataleptogenic effect of anandamide by phenylmethylsulfonyl fluoride Biol. Pharm. Bull. 22,366-370頁 (共著) 1999
論文	Synthesis and central nervous system depressant effects of N3-substituted 2',3'-O-isopropylideneuridines Chem. Pharm. Bull. 47,1802-1804頁 (共著) 1999
論文	Synthesis and pharmacological evaluation in mice of halogenated cannabidiol derivatives Chem. Pharm. Bull. 47,1641-1645頁 (共著) 1999
論文	Anandamide, an endogenous cannabinoid receptor ligand, also interacts with 5-hydroxytryptamine (5-HT) receptor Biol. Pharm. Bull. 21,224-226頁 (共著) 1998
論文	Antianxiety effects of N³-phenacyluridine in mice Nucleic Acid Symposium Series 39,195-196頁 (共著) 1998
論文	Competitive inhibition of Δ8-tetrahydrocannabinol and its active metabolites for cannabinoid receptor binding Biol. Pharm. Bull. 21,408-410頁 (共著) 1998
論文	Synthesis and pharmacological activities in mice of halogenated Δ9-tetrahydrocannabinol derivatives Chem. Pharm. Bull. 46,1462-1467頁 (共著) 1998
論文	Synthesis and sedative-hypnotic effects of N3-allyl- and N1-allyl-5,6-substituted 2-thiouracil derivatives. Chem. Pharm. Bull. 46,1370-1373頁 (共著) 1998
論文	Hypnotic activities of N³-benzyl and xylyl substituted arabinofuranosyluracil Nucleic Acid Symposium Series 37,223-230頁 (共著) 1997
論文	Central nervous system depressant of N3-substituted derivatives of deoxyuridine in mice Biol. Pharm. Bull. 19,142-145頁 (共著) 1996
論文	Changes in 5-HT receptor binding induced by tetrahydrocannabinol metabolites in bovine cerebral cortex Res. Commun. Alchohol Subst. Abuse 17,57-69頁 (共著) 1996
論文	Hypnotic mechanism of N³-phenacyluridine: formation of active metabolites and their binding affinity n synaptic membrane Nucleic Acid Symposium Series 35,61-62頁 (共著) 1996
論文	N3-Phenacyluridine, a novel hypnotic compound, interacts with the benzodiazepine receptor Eur. J. Pharmmacol. 311,265-269頁 (共著) 1996
論文	Binding affinity of N³-substituted uridine for synaptic membrane and their CNS depressant effects Nucleic Acid Symposium Series 34,147-148頁 (共著) 1995
論文	Binding characteristics of [3H]flunitrazepam in pentobarbital-withdrawal rats Neurochem. Res. 19,37-42頁 (共著) 1994
論文	Hypnotic activities of N³-phenacyluridine and its related compounds Nucleic Acid Symposium Series 31,93-94頁 (共著) 1994
論文	Interactions of Ginsenosides with ligand-binding of GABAA and GABAB receptors Gen. Pharmacol. 25,193-199頁 (共著) 1994
論文	Synthesis and hypnotic and anti-human immunodeficiency Virus-1 activities of N3-substituted 2'-Deoxy-2'-fluorouridines Chem. Pharm. Bull. 42,595-598頁 (共著) 1994
論文	The potent depressant effects of N3-phenacyluridine in mice Biol. Pharm. Bull. 17,514-516頁 (共著) 1994
論文	Induction of tolerance to and physical dependence on pentobarbital continuous intracerebroventricular administration J. Pharmacol. Exp. Ther. 266,1300-1305頁 (共著) 1993
論文	N3-Phenacyluridine, a novel hypnotic compound, interacts with the benzodiazepine receptor Res. Commun. Psychol. Psychiat. Behav. 18,111-119頁 (共著) 1993
論文	Preparation and pharmacological evaluation of N3-substituted thymidine derivatives as central depressants Chem. Pharm. Bull. 41,1180-1182頁 (共著) 1993
論文	Receptors of uridine and its derivatives Sleep Research 22,512 (共著) 1993
論文	Sedative and hypnotic activities of pyrimidine nucleoside derivatives Nucleic Acid Symposium Series 29,51-52頁 (共著) 1993
論文	Sleep promoting effects of N³-Benzyluridine in unrestrained rats Res. Commun. Psychiat. Behav. 18,111-119頁 (共著) 1993
論文	The interaction of uridine derivatives with benzodiazepine receoter in the synaptic membrane Sleep Research 22,497 (共著) 1993
論文	ウシ大脳皮質シナプス膜画分におけるウリジン及び誘導体　-特異的結合活性-　ウリジン受容体の検索岡崎国立共同研究機構生理学研究所年報 13,448 (共著) 1993
論文	テトラヒドロカンナビノール及び活性代謝物の中枢系レセプター結合に及ぼす影響法中毒 11 (共著) 1993
論文	6-Azauridine analogues possessing sedative and hypnotic effects Nucleic Acid Symposium Series 27,199-200頁 (共著) 1992
論文	Cannabinoid metabolite interacted with benzodiazepine receptor Res. Commun. Subst. Abuse 13,299-313頁 (共著) 1992
論文	Effects of pentobarbital tolerance on convulsant and GABA_A receptor antagonist binding Life Sci. 50,1701-1709頁 (共著) 1992
論文	ウラシル誘導体の合成及びマウスにおける中枢抑制作用　新鎮静・催眠薬の開発に関する研究（第２報）薬学雑誌 112,470-478頁 (共著) 1992
論文	ウリジン及びその誘導体の睡眠作用-ウリジン受容体は存在するか？- 岡崎国立共同研究機構生理学研究所年報 13,448 (共著) 1992
論文	新規睡眠物質 N3-benzylthymidine の睡眠作用と体内動態薬物動態 7,577-590頁 (共著) 1992
論文	Binding characteristics of [³H]flunitrazepam in pentobarbital-withdrawal rats Pharmacologist 32,192 (共著) 1991
論文	Central depressant effects of N3-substituted 6-azauridines in mice Chem. Pharm. Bull. 39,2597-2599頁 (共著) 1991
論文	Chronic nandrolone induces heart changes and affects brain GABA receptor binding in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) Pharmacologist 32,149 (共著) 1991
論文	Effects of pentobarbital tolerance to and dependence on GABA_B receptor binding Neurochem. Res. 16,1133-1137頁 (共著) 1991
論文	In vivo and in vitro metabolic studies of N3-benzyluridine which exhibits hypnotic activity in mice Res. Commun. Chem. Pathol. Pharmacol. 71,27-48頁 (共著) 1991
論文	N³-Benzyl-thymidine及び N^３-BenzyldeoxyuridineとGABA_A[並びにベンゾジアゼピンレセプターとの相互作用岡崎国立共同研究機構生理学研究所年報 12,403 (共著) 1991
論文	The nucleoside derivatives possessing sedative and hypnotic effects Nucleic Acid Symposium Series 25,96-96頁 (共著) 1991
論文	より強力な鎮静、睡眠作用を有するN³-置換ウリジン及びチミジン及びデオキシウリジン誘導体の合成と薬理効果岡崎国立共同研究機構生理学研究所年報 12,402-403頁 (共著) 1991
論文	Effects of ginsenosides on GABAA and GABAB receptor Korean J. Ginseng Sci. 14,213-216頁 (共著) 1990
論文	Effects of N-allyl-substituted purines on the drug-induced sleep and spontaneous activity Res. Commun. Psychol., Psychiat. Behav. 15,30-40頁 (共著) 1990
論文	Effects of pentobarbital tolerance and withdrawal GABA_A receptor agonist binding FASEB Journal 4,A1131 (共著) 1990
論文	Effects of pentobarbital tolerance and withdrawal on GABA_B receptor Eur. J. Pharmacol. 183,466 (共著) 1990
論文	Hypnotic and sedative activities of N3-substituted uridine thymidine and azauridine, and their action mechanism Eur. J. Pharmacol. 183,1559 (共著) 1990
論文	Induction of tolerance to and physical dependence on pentobarbital by continuous intracerebroventricular (i.c.v.) administration Pharmacologist 32,125 (共著) 1990
論文	Studies on the effects of pentobarbital tolerance and withdrawal on GABA_B receptor FASEB Journal 4,A1131 (共著) 1990
論文	ウリジン、チミジン及びウリジン誘導体の睡眠作用とその作用機序岡崎国立共同研究機構生理学研究所年報 11,412 (共著) 1990
論文	Effects of N1,N3-diallyluracil and N1,N3-diallylthymine on hepatic drug-metabolizing enzymes on mic Res. Commun. Chem. Pathol. Pharmacol. 64,135-143頁 (共著) 1989
論文	N,N'-Diallylpentobarbital (DAPB) metabolites and their effects on pentobarbital-induced sleep and hepatic drug-metabolizing enzyme Xenobiotica 19,1355-1368頁 (共著) 1989
論文	Structure-activity relationships of uridine derivatives for hypnotic activity Journal Pharmacobio Dynamics 12,s135 (共著) 1989
論文	核酸誘導体の睡眠作用メカニズム（その２）岡崎国立共同研究機構生理学研究所年報 10,350 (共著) 1989
論文	Hypnotic activity of N3-benzylthymidine on mice Life Sci. 41,2791-2797頁 (共著) 1988
論文	N3-Benzyluridine(N3-ByUd)の生体内動態並びに睡眠作用機構-脳 in vivo代謝及びベンゾジアゼピンレセプター（BZP-R）に対する影響薬物動態 3,630-631頁 (共著) 1988
論文	核酸誘導体の睡眠作用発現とそのメカニズム岡崎国立共同研究機構生理学研究所年報 9,370-370頁 (共著) 1988
論文	Central effects of N-substituted derivatives of 2,6-dioxopiperidine in mice Res. Commun. Chem. Pathol. Pharmacol. 57,173-185頁 (共著) 1987
論文	Comparison of sleep-promoting activity of uridine-related substances in unrestrained rats Sleep Research 16,62-62頁 (共著) 1987
論文	Mechanism of N,N'-diallylpentobarbital potentiation of pentobarbital-induced sleep in mice Res. Commun. Chem. Pathol. Pharmacol. 57,173-185頁 (共著) 1987
論文	N-Substituted oxopyrimidines and nucleosides: structure-activity relationship for hypnotic activity as central nervous system depressant J. Med. Chem. 30,2227-2231頁 (共著) 1987
論文	Potentiating effects of N1,N3-diallyluracil, N1,N3-diallylthymine and N1,N1-diallyl-6-methyluracil on pentobarbital-induced sleep and diazepam-induced motor incoordination Chem. Pharm. Bull. 35,4928-4934頁 (共著) 1987
論文	Potentiation of barbiturate-induced narcosis by N,N'-(or N,S-) diallyl-substituted derivatives of phenobarbital, amobarbital and thiopental in mice Chem. Pharm. Bull. 35,778-784頁 (共著) 1987
論文	Barbituric acid 及び　N,5,5-Triallylbarbituric acid のマウスにおける中枢抑制作用薬学雑誌 106,504-510頁 (共著) 1986
論文	Central depressant activity of N3-allyluridine and N3-allylthymidine Res. Commun. Chem. Pathol. Pharmacol. 52,321-332頁 (共著) 1986
論文	Central effects of N-allyl,N'-methyl-barbital and N-allylmethyprylon in mice Res. Commun. Chem. Pathol. Pharmacol. 54,191-199頁 (共著) 1986
論文	N3-Benzyluridine exerts hypnotic activity in mice Chem. Pharm. Bull. 33,4088-4090頁 (共著) 1985
その他	衛生化学・環境健康学・公衆衛生学講義ブック　生化学〜食品衛生学〜環境学〜公衆衛生学　第６版 (単著) 2020/04
その他	衛生化学･環境健康学･公衆衛生学講義ブック　生化学〜食品衛生学〜環境学〜公衆衛生学第５版 (単著) 2019/09
その他	衛生化学・環境健康学講義ブック　生化学〜食品衛生学〜環境学　第4版 (単著) 2019/03
その他	CBT対策と演習　衛生薬学Ⅰ (共著) 2009
その他	CBT対策と演習　衛生薬学Ⅱ (共著) 2009
その他	衛生化学講義ブック　生化学から食品衛生まで　第2版 (単著) 2009
その他	新衛生薬学系実習新衛生薬学系実習 (共著) 2006
その他	Pharmacology and toxicology of major constituents of Marijuana - On the metabolic activation of cannabinoids and its mechanism J. Toxicol. Toxin Rev. (共著) 2003
その他	Uridine receptor: Discovery and its involvement in sleep mechanism Sleep 24,251-260頁 (共著) 2001