教員情報 - 深井　原

フカイ　モト Fukai Moto
深井　原

所属藤女子大学ウェルビーイング学部食環境マネジメント学科

職種教授

著書・論文歴
論文	Inhibition of thromboxane A2 synthesis by OKY-046 attenuates ischemia and reperfusion injury of the liver. Transplantation Proceedings 31,1061-1062頁 (共著) 1999
論文	Dose-dependent study of a novel immunosuppressant, FTY720, with the canine renal allograft transplantation model. Transplantation Proceedings 31,1208-1209頁 (共著) 1999
論文	A short-course therapy with FTY720 prolongs allograft survival after canine kidney transplantation. Transplantation Proceedings 31,2783-2784頁 (共著) 1999
論文	Prolongation of canine liver allograft survival by a novel immunosuppressant, FTY720: effect of monotherapy and combined treatment with conventional drugs. Transplantation 69,235-241頁 (共著) 2000
論文	A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery 127 (6),661-669頁 (共著) 2000
論文	Protective effect of angiotensin II type I receptor antagonist, CV-11974, on ischemia and reperfusion injury of the liver. Transplantation 71,1034-1039頁 (共著) 2001
論文	Attenuation of ischemia and reperfusion injury of canine livers by inhibition of type II phospholipase A2 with LY329722. Transplantation 71,1040-1046頁 (共著) 2001
論文	A novel inhibitor of Rho-associated protein kinase, Y-27632, ameliorates hepatic ischemia and reperfusion injury in rats. Surgery 133,197-206頁 (共著) 2003
論文	A new immunosuppressant, FTY720, in canine kidney transplantation: effect of single-drug, induction and combination treatments. Transplant International 17,574-584頁 (共著) 2004
論文	Lipid peroxidation during ischemia depends on ischemia time in warm ischemia and reperfusion of rat liver. Free Radical Biology and Medicine 38,1372-1381頁 (共著) 2005
論文	ラット肝温阻血再灌流モデルにおいて、阻血中の脂質過酸化は阻血時間に依存する (単著) 2005/12/26
論文	Ex vivo adenoviral gene transfer of constitutively activated STAT3 reduces post-transplant liver injury and promotes regeneration in a 20% rat partial liver transplant model. Transplant International 19 (5),415-423頁 (共著) 2006
論文	The effect of antagonism of adenosine A1 receptor against ischemia and reperfusion injury of the liver. Journal of Surgical Research 139 (1),7-14頁 (共著) 2007
論文	The novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reperfusion in rats. Journal of Surgical Research 149 (1),69-75頁 (共著) 2008
論文	Preventing hypoxia/reoxygenation damage to hepatocytes by p66(shc) ablation: up-regulation of anti-oxidant and anti-apoptotic proteins. Journal of Hepatology 48 (3),422-432頁 (共著) 2008
論文	Identification of de novo STAT3 target gene in liver regeneration. Hepatology Research 38 (4),374-384頁 (共著) 2008
論文	A simple and reliable method for determining plasma concentration of dehydroxymethylepoxyquinomicin by high performance liquid chromatography with mass spectrometry. Journal of Chromatography B Analytical Technologies in the Biomedical Life Sciences 871 (1),32-36頁 (共著) 2008
論文	Successful transplantation of rat hearts subjected to extended cold preservation with a novel preservation solution. Transplant International 25 (6),696-706頁 (共著) 2012
論文	Does heavy water attenuate cold preservation and reperfusion injury in canine kidney? Low Temperature Medicine 38 (3),62-68頁 (共著) 2012
論文	A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice. Journal of Crohns and Colitis 6 (12),315-25頁 (共著) 2012
論文	Hydrogen sulfide augments survival signals in warm ischemia and reperfusion of the mouse liver. Surgery Today 45 (7),892-903頁 (共著) 2015
論文	Human Amnion-derived Mesenchymal Stem Cell Transplantation. Ameliorates Liver Fibrosis in Rats. Transplantation Direct 1 (4),e16-e24頁 (共著) 2015
論文	Clinicopathological characteristics and diagnostic performance of Wisteria floribunda agglutinin positive Mac-2-binding protein as a preoperative serum marker of liver fibrosis in hepatocellular carcinoma. Journal of Gastroenterology 50 (11),1134-1144頁 (共著) 2015
論文	3-[(Dodecylthiocarbonyl)Methyl]-Glutarimide Attenuates Graft Arterial Disease by Suppressing Alloimmune Responses and Vascular Smooth Muscle Cell Proliferation. Transplantation 99 (5),948-956頁 (共著) 2015
論文	Strong cytoplasmic expression of NF-κB/p65 correlates with a good prognosis in patients with triple-negative breast cancer. Surgery Today 46 (7),843-851頁 (共著) 2016
論文	Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl] -glutarimide ameliorates murine models of inflammatory bowel disease. Inflammation Research 65 (3),245-260頁 (共著) 2016
論文	Interleukin-34 as a fibroblast-derived marker of liver fibrosis in patients with non-alcoholic fatty liver disease. Scientific Report 6,28814-28825頁 (共著) 2016
論文	Hydrogen gas ameliorates hepatic reperfusion injury after prolonged cold preservation in isolated perfused rat liver. Artificial Organs 40 (2),1128-1136頁 (共著) 2016
論文	14-3-3ζ-mediated stimulation of oxidative phosphorylation exacerbates oxidative damage under hypothermic oxygenated conditions in human renal tubular cells (HK-2). Transplantation Proceedings 48 (4),1288-1291頁 (共著) 2016
論文	Pro-angiogenic TIE-2-expressing monocytes/TEMs as a biomarker of the effect of sorafenib in patients with advanced hepatocellular carcinoma. International Journal of Cancer 145 (1),1011-1017頁 (共著) 2017
論文	Fatty acid-binding protein 5 function in hepatocellular carcinoma through induction of epithelial-mesenchymal transition. Cancer Medicine 6 (5),1049-1061頁 (共著) 2017
論文	Copy Number Profiles of Paired Primary and Metastatic Colorectal Cancers Oncotarget 9 (3),3394-3405頁 (共著) 2017
論文	Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study. Surgery Today 48 (12),1081-1088頁 (共著) 2018
論文	Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma. Scientific Report 8 (1),7958-7965頁 (共著) 2018
論文	USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation. Journal of Virology. Journal of Virology 93 (6),e01708-e01718頁 (共著) 2019
論文	Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients with hepatocellular carcinoma. Scientific Report 9 (1),15788-15800頁 (共著) 2019
論文	Heavy water (D2O) containing preservation solution reduces hepatic cold preservation and reperfusion injury in an isolated perfused rat liver (IPRL) model. Journal of Clinical Medicine 8 (11),1818-1829頁 (共著) 2019
論文	Triazolopyrimidine derivative NK026680 and donor-specific transfusion induces CD4+CD25+Foxp3+ T cells and ameliorates allograft rejection in an antigen-specific manner. Transpl Immunology 65,101338-101350頁 (共著) 2020
論文	Role of Wnt5a in suppressing invasiveness of hepatocellular carcinoma via epithelial-mesenchymal transition. Oncology Letters 20 (5),268-277頁 (共著) 2020
論文	Prognostic impact of CD8+ T cell distribution and its association with the HLA class I expression in intrahepatic cholangiocarcinoma. Surgery Today 50 (8),931-940頁 (共著) 2020
論文	Novel immunological approach to asses donor reactivity of transplant recipients using a humanized mouse model. Human Immunology 81 (7),342-353頁 (共著) 2020
論文	Imaging Mass Spectrometry Reveals the Changes in the Taurine Conjugates of Dihydroxycholanoic Acid During Hepatic Warm Ischemia and Reperfusion in a Rat Model. Transplantation Proceedings 52 (6),1880-1883頁 (共著) 2020
論文	Establishment of a cell culture model permissive for infection by hepatitis B and C viruses. Hepatology Communucations 5 (4),634-649頁 (共著) 2020
論文	Analysis of the correlation between alterations in N‑glycans and invasiveness in liver cancer cell lines. Oncology Reports 44 (6),2757-2769頁 (共著) 2020
論文	The Phenolic Antioxidant 3,5-dihydroxy-4-methoxybenzyl Alcohol (DHMBA) Prevents Enterocyte Cell Death under Oxygen-Dissolving Cold Conditions through Polyphyletic Antioxidant Actions. Journal of Clinical Medicine 10 (9),1972-1988頁 (共著) 2021
論文	Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level. Carcinogenesis 42 (6),794-803頁 (共著) 2021
論文	Prognostic significance of circulating tumor cells with mesenchymal phenotypes in patients with gastric cancer: a prospective study. Annals of Surgical Oncology 28 (2),1178-1186頁 (共著) 2021
論文	Myostatin as a fibroblast-activating factor impacts on postoperative outcome in patients with hepatocellular carcinoma. Hepatology Research 51 (7),803-812頁 (共著) 2021
論文	Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells. BMC Cancer 21 (1),200-215頁 (共著) 2021
論文	Genomewide transcriptomic profiling identifies a gene signature for predicting recurrence in early-stage hepatocellular carcinoma. Clinical and Translational Medicine 11 (6),e405-e412頁 (共著) 2021
論文	Early administration of amatuximab, a chimeric high-affinity anti-mesothelin monoclonal antibody, suppresses liver metastasis of mesothelin-expressing pancreatic cancer cells and enhances gemcitabine sensitivity in a xenograft mouse model. Investigational New Drugs 39 (5),1256.-1266頁 (共著) 2021
論文	Versican Secreted by Cancer-Associated Fibroblasts is a Poor Prognostic Factor in Hepatocellular Carcinoma. Annals of Surgical Oncology 29 (11),7135-7146頁 (共著) 2022
論文	Quantification of DNA methylation for carcinogenic risk estimation in patients with non-alcoholic steatohepatitis. Clinical epigenetics 14 (1),168-184頁 (共著) 2022
論文	Warm Ischemia Induces Spatiotemporal Changes in Lysophosphatidylinositol That Affect Post-Reperfusion Injury in Normal and Steatotic Rat Livers. Journal of Clinical Medicine 12 (9),3163-3178.頁 (共著) 2023
論文	Rapid and Reliable Steatosis Rat Model Shrsp5-Dmcr for Cold Storage Experiment Transplantation Proceedings 55 (4),1032-1035頁 (共著) 2023
論文	Important constituents of a heavy water-containing solution for cold storage and subsequent reperfusion on an isolated perfused rat liver. Transplantation Proceedings 56 (1),223-227頁 (共著) 2023
論文	Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function. Transplantation Proceedings 55 (4),1016-1020頁 (共著) 2023
論文	Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers. Transplantation Proceedings 55 (4),1027-1031頁 (共著) 2023
論文	TCF1highPD-1+Ly108+CD8+ T Cells Are Associated with Graft Preservation in Sensitized Mice Treated with Non-Fc Receptor-Binding CD3 Antibodies. Immunohorizons. 8 (4),295-306頁 (共著) 2024
論文	Role of heavy water in modified University of Wisconsin solution for extended cold storage of rat liver. 56 (8),1890-1895頁 (共著) 2024
論文	Expression Analysis of Early Metastatic Seeding of Colorectal Cancer. Annals of Surgical Oncology 31 (3),2101-2113頁 (共著) 2024
論文	Folate receptor 1 is a stemness trait-associated diagnostic and prognostic marker for hepatocellular carcinoma. Biomarker research 13,37-52頁 (共著) 2025
論文	Exploration of Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved after Circulatory Death. Journal of Clinical Medicine 12 (11),3845-3859頁 (共著) 2023
著書	Molecular Hydrogen for Medicine-The Art of Ancient Life Revived (共著) 2020
著書	移植のための臓器摘出と保存 (浅野武秀　監修、福嶌教偉、剣持敬、絵野沢伸編),11-20頁 (共著) 2012
論文	臓器灌流保存における温度とpHの関係を紐解く Organ Biology 31 (2),99-105頁 (単著) 2024
論文	臓器灌流法、臓器機能評価法を如何に読み解くか北海道外科雑誌 68 (2),1-6頁 (共著) 2024
論文	Adenomatous polyposis coli-binding protein end-binding 1 promotes hepatocellular carcinoma growth and metastasis. PLoS One 15 (9),e0239462-e0239479頁 (共著) 2020
論文	脂肪肝虚血再灌流障害をターゲットとしたAMPKの役割 Organ Biology 25 (2),134-139頁 (共著) 2018
論文	臓器灌流法の先にあるべき技術とは？ Organ Biology 24 (2),49-54頁 (共著) 2017
論文	腎臓灌流保存装置の臨床現場への導入に関するアンケート調査報告 Organ Biology 24 (1),70-75頁 (共著) 2016
論文	低温酸素化状態におけるタンパク機能制御 Organ Biology 23 (2),173-179頁 (共著) 2016
論文	【肝疾患の病態と糖鎖科学の意義】肝細胞癌切除症例における新規血清肝線維化マーカーM2BPGi測定の有用性の検討肝胆膵 70 (55),39-44頁 (共著) 2015
論文	臓器保存におけるオートファジーの病態と評価法 Organ Biology 22 (2),26-31頁 (共著) 2015
論文	【肝胆膵領域におけるNF-κB研究の最前線】肝再生におけるNF-κBの作用　肝移植におけるNF-κB活性の功罪肝胆膵 68 (4),563-568頁 (共著) 2014
論文	よりよい臓器灌流のための臓器保存法と再灌流時治療― 重水、水素、ヘリウムの生物活性 Organ Biology 21 (2),159-165頁 (共著) 2014
論文	臓器保存液の現状と今後～単純冷保存は役割を終えたのか？ Organ Biology 20 (2),176-180頁 (共著) 2013
論文	臓器の保存から修復への試み～ミトコンドリア機能と細胞内Ca2+の重要性 Organ Biology 19 (1),70-75頁 (共著) 2012
論文	移植臓器の非侵襲的モニタリング法の開発 Organ Biology 18 (1),134-140頁 (共著) 2011
論文	臓器保存における重水の可能性—Possible cytoprotective actions of heavy water in organ preservation Organ Biology 18 (1),101-107頁 (共著) 2011
論文	臓器保存の現状と今後--新しい保存法開発のための基礎知識 (第5土曜特集臓器移植の新時代) -- (研究の新しい展開) 医学のあゆみ 237 (1),583-591頁 (共著) 2011
論文	肝移植における虚血・再灌流障害のシグナル伝達機構臨床化学 37 (2),131-140頁 (共著) 2008
論文	【虚血による臓器障害その修復機転】　薬剤による保存障害の回避. Surgery Frontier 11,251-258頁 (共著) 2004
論文	難治性寄生虫症　多包性エキノコックス症の診断と治療. Clinical Parasitology 13,32-36頁 (共著) 2003
論文	【肝移植:現況と展望】　現況と展望　脳死肝移植. 日本内科学会雑誌90: 21-28, 2001. 90,21-28頁 (共著) 2001
論文	【肝疾患の長期予後】多包性肝エキノコックス症の長期予後肝胆膵 37 (6),1021-1030頁 (共著) 1998
論文	嚢胞内乳癌症例の検討北海道外科雑誌 40 (1),13-17頁 (共著) 1995